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Epidemiology

Epidemiology

jwatch.org

Characterizing COVID-19 Breakthrough Infections

Source: NEJM

Report on peer review article This report provides reassuring data that the few symptomatic post-vaccination infections in studied health care worker were mild; moreover, those with asymptomatic infections could alternatively...

nejm.org

Delayed Large Local Reactions to mRNA Covid-19 Vaccines in Blacks, Indigenous Persons, and People of Color

Source: NEJM

Delayed large local reactions may be less commonly recognized or reported in Black indigenous and people of colour (BIPOC) vaccine recipients than in White recipients. Such reactions may result in...

thelancet.com

COVID-19 and the effects on pulmonary function following infection: A retrospective analysis

Source: Lancet

Peer review article This study showed that there is no difference in pulmonary function as measured by function tests before and after COVID-19 infection in non-critically ill classified patients. There...

thelancet.com

How reliable are COVID-19 burden estimates for India?

Source: Lancet

Opinion piece With nearly 31 million reported COVID-19 cases and 410 000 deaths, India is one of the countries with the heaviest burden of COVID-19 cases and deaths. There is...

thelancet.com

Antiphospholipid antibodies and neurological manifestations in acute COVID-19: A single-centre cross-sectional study

Source: Lancet

Peer review article A high prevalence of antiphospholipid antibodies (ones that attack cell membrane) has been reported in case series of patients with neurological manifestations and COVID-19; however, the pathogenicity...

thelancet.com

Safety and immunogenicity of the ChAdOx1 nCoV-19 (AZD1222) vaccine against SARS-CoV-2 in people living with and without HIV in South Africa: an interim analysis of a randomised, double-blind, placebo-controlled, phase 1B/2A trial

Source: Lancet

Peer review article ChAdOx1 nCoV-19 (Oxford/AstraZeneca) was well tolerated, showing favourable safety and immunogenicity in people with HIV, including heightened immunogenicity in SARS-CoV-2 baseline-seropositive participants. People with HIV showed cross-reactive...

thelancet.com

COVID-19, smoking, and cancer: a dangerous liaison

Source: Lancet

Opinion piece The consequences of the COVID-19 pandemic have worsened an already unacceptable global burden of disease for respiratory cancers, as well as highlighting substantial global health inequities, which continue...

thelancet.com

The long-term sequelae of COVID-19: an international consensus on research priorities for patients with pre-existing and new-onset airways disease

Source: Lancet

Peer review article Robust expert consensus process to identify research priorities for long COVID in the context of airways disease, taking into account the views of a large group of...

blogs.bmj.com

Transitioning from covid-19 elimination to sustainable endemicity in East Asia

Source: BMJ

Twenty months into the Covid-19 pandemic, and many countries in East Asia are now looking forward past the current “zero covid” policy that has characterised the pre-vaccine phase, and towards...

bmj.com

Covid-19: How many variants are there, and what do we know about them?

Source: BMJ

Eight notable variants of SARS-CoV-2 have been found since September 2020. This video explainer describes them all.

bmj.com

Covid-19: Fully vaccinated people can carry as much delta virus as unvaccinated people, data indicate

Source: BMJ

Adults who have been fully vaccinated against SARS-CoV-2 can carry the same viral load of the delta variant as those who are unvaccinated, a preliminary analysis of UK data suggests

bmj.com

Covid-19: China pressured WHO team to dismiss lab leak theory, claims chief investigator

Source: BMJ

A World Health Organisation mission to study the Covid-19 pandemic’s origins in China, which announced in February that the possibility that the virus had escaped from a laboratory needed no...

cdc.gov

COVID-19 Science Update released: August 13, 2021 Edition 102

Source: US CDC

Report on 2 peer review articles and 6 pre-release peer review articles Peer review article Although COVID-19 duration is usually short in children, some children experience prolonged illness. SARS-CoV-2 variants...

cdc.gov

Investigation of Long-Term Effects of Myocarditis after mRNA COVID-19 Vaccination

Source: US CDC

CDC is actively investigating reports of people developing myocarditis (inflammation of the heart muscle) after receiving a mRNA COVID-19 vaccine (Pfizer-BioNTech or Moderna). Most of these people fully recover, but...

cdc.gov

Delta Variant: What We Know About the Science

Source: US CDC

The Delta variant is more contagious Some data suggest the Delta variant might cause more severe illness than previous strains in unvaccinated persons. Unvaccinated people remain the greatest concern Fully...

cdc.gov

COVID-19 Science Update released: August 20, 2021 Edition 103

Source: US CDC

Report on 4 peer review articles and 2 prerelease peer review articles Adolescents vaccinated with 2 doses of mRNA-1273 (Moderna) had immunogenicity and vaccine efficacy comparable to young adults, with...

who.int

Post COVID-19 condition: WHO supports standardization of clinical data collection and reporting

Source: WHO

The World Health Organization is working with researchers to address the urgent need to streamline data collection and reporting on Post COVID-19 condition, also known as ‘long COVID’. A significant...

who.int

WHO Statement on advancing the next series of studies to find the origins of SARS-CoV-2

Source: WHO

Following the publication of the WHO-China joint report of the phase one studies on the origins of the SARS-CoV-2 virus in March 2021, WHO has outlined the next series of...

poynter.org

Fauci did not say there was a COVID-19 variant that can evade detection

Source: Poynter

Despite a viral Facebook post's claim, we found no evidence of Dr. Anthony Fauci saying anything about any variants that could avoid detection

poynter.org

CDC test can’t differentiate between COVID and the flu? That’s wrong.

Source: Poynter

Posts circulating on Facebook and Instagram claim the Centers for Disease Control and Prevention will stop using its COVID-19 test because it cannot differentiate between the COVID virus and flu...

fullfact.org

There are ways of testing for the Delta variant

Source: Full Fact

WHAT WAS CLAIMED There is no Delta variant test. OUR VERDICT Genetic analysis of positive tests allow scientists to identify different variants of Covid-19, including the Delta variant.

jwatch.org

Does Diminished Nasopharyngeal Antiviral Immunity Precede Severe COVID-19?

Source: NEJM

Report on peer review article Certain people develop a very fast rate of viral growth in their noses. Finding out what causes this is important. In addition to enhancing our...

jwatch.org

COVID-19 Is Associated with Increased Vascular Risk

Source: NEJM

Report on peer review article This nationwide study provides evidence that COVID-19 is a risk factor for heart attack and stroke. We need to learn how long this risk persists...

thelancet.com

Childhood obesity beyond COVID-19

Source: Lancet

Opinion piece As children return to schools, these institutions could play an even more important part in delivering healthy nutrition, and physical and food education. Importantly, there is an opportunity...

thelancet.com

Mucormycosis after COVID-19 in a patient with diabetes

Source: Lancet

Case study of COVID-19 linked fungal infection. COVID-19 followed by mucormycosis carries a very high mortality rate and timely detection, antifungal therapy, and aggressive surgical debridement remain key factors in...

thelancet.com

Risk factors for COVID-19-related in-hospital mortality in a high HIV and tuberculosis prevalence setting in South Africa: a cohort study

Source: Lancet

Peer review article Individuals identified as being at high risk of COVID-19 in-hospital mortality (older individuals and those with chronic comorbidities and people with HIV, particularly those not on antiretrovirals)...

thelancet.com

Long Covid in adults discharged from UK hospitals after Covid-19: A prospective, multicentre cohort study using the ISARIC WHO Clinical Characterisation Protocol

Source: Lancet

Peer review article This study sought to establish the long-term effects of Covid-19 following hospitalisation. 55% of participants reported not feeling fully recovered. 93% reported persistent symptoms, with fatigue the...

thelancet.com

The foreseen loss of the battle against COVID-19 in South America: A foretold tragedy

Source: Lancet

Opinion piece In South America, strained and underfunded health systems, deep social inequalities and increasing poverty, slow vaccination rates and increased spread of new variants are leading to a surge...

thelancet.com

Upregulation of pulmonary tissue factor, loss of thrombomodulin and immunothrombosis in SARS-CoV-2 infection

Source: Lancet

Peer review article SARS-CoV-2 infection is associated with clotting and complications on small blood vessels. The cause of clotting in the disease is incompletely understood. It appears there may be...

bmj.com

Covid-19: Delta infections threaten herd immunity vaccine strategy

Source: BMJ

Epidemiologists are adjusting their expectations for the future course of the pandemic after data from a recent outbreak in Massachusetts in the US suggest that while vaccination remains highly protective...

bmj.com

Covid-19: Most symptomatic children recover within a week, study finds

Source: BMJ

Report on peer review article Most children who test positive for covid-19 and experience symptoms recover within a week, although a small proportion are unwell for more than four weeks,...

cdc.gov

Animals and COVID-19

Source: US CDC

Based on the available information to date, the risk of animals spreading SARS-CoV-2, the virus that causes COVID-19, to people is considered to be low. We are still learning about...

cdc.gov

Delta Variant: What We Know About the Science

Source: US CDC

The Delta variant is highly contagious, nearly twice as contagious as previous variants. In two different studies from Canada and Scotland, patients infected with the Delta variant were more likely...

afro.who.int

Record weekly COVID-19 deaths in Africa

Source: WHO Africa

Weekly COVID-19 deaths in Africa reached a record peak in the week that ended on 1 August, marking the highest seven-day toll since the onset of the pandemic in the...

fullfact.org

Covid-19 mutated long before mass vaccine roll-outs

Source: Full Fact

WHAT WAS CLAIMED Covid-19 barely mutated before vaccines were rolled out. OUR VERDICT This is untrue. All four variants of concern, designated as such by the World Health Organisation, were...

fullfact.org

Why school testing data doesn’t tell the whole story

Source: Full Fact

WHAT WAS CLAIMED 80% of children in England are not being tested for coronavirus. OUR VERDICT This is based on data which only includes tests reported, not the number of...

fullfact.org

A Portuguese court hasn’t said there have only been 152 Covid deaths

Source: Full Fact

WHAT WAS CLAIMED A Lisbon court found only 152 deaths have been caused by Covid-19 in Portugal. OUR VERDICT False. A Lisbon court found doctors from the Ministry of Justice...

fullfact.org

A fall in death rates doesn’t prove Covid-19 isn’t killing anyone

Source: Full Fact

WHAT WAS CLAIMED Death rates in England and Wales are lower than previous years, which proves Covid-19 hasn’t killed or is killing anyone. OUR VERDICT While death rates in England...

fullfact.org

Young people do face a small risk from Covid

Source: Full Fact

WHAT WAS CLAIMED Young people are not at risk from Covid-19 at all. OUR VERDICT Incorrect. Both children and young adults face a very low risk of death or serious...

fullfact.org

Average Covid-19 victim dies years before they otherwise would

Source: Full Fact

WHAT WAS CLAIMED The average age of Covid-19 deaths is higher than the average life expectancy, which means that people who get Covid live longer. OUR VERDICT This isn’t how...

ncdc.gov.ng

Confirmed Case of Delta Variant Detected in Nigeria

Source: Nigeria CDC

The Nigeria Centre for Disease Control (NCDC) has detected a confirmed case with the SARS-CoV-2 Delta variant, also known as lineage B.1.617.2. The variant was detected in a traveler to...

nejm.org

SARS-CoV-2 Variants and Vaccines

Source: NEJM

Viral variants of concern may emerge with dangerous resistance to the immunity generated by the current vaccines to prevent coronavirus disease 2019 (Covid-19). Moreover, if some variants of concern have...

nice.org.uk

https://www.nice.org.uk/guidance/ng200

Source: NICE

This guideline covers vaccine-induced immune thrombocytopenia and thrombosis (VITT - blood clotting events)), a syndrome which has been reported in rare cases after COVID-19 vaccination. VITT may also be called...

ecdc.europa.eu

SARS-COV-2 Delta variant now dominant in much of the European Region and efforts must be reinforced to prevent transmission, warn WHO/Europe and ECDC

Source: EU CDC

The SARS-COV-2 Delta variant of concern is spreading quickly across Europe and has now become the dominant strain across much of the region, according to new data.

thelancet.com

Neutralisation of SARS-CoV-2 lineage P.1 by antibodies elicited through natural SARS-CoV-2 infection or vaccination with an inactivated SARS-CoV-2 vaccine: an immunological study

Source: Lancet

Peer review article SARS-CoV-2 lineage P.1 (Gamma variant) might escape neutralisation by antibodies generated in response to polyclonal stimulation (where multiple types of white blood cell can target the same...

thelancet.com

Difference in mortality among individuals admitted to hospital with COVID-19 during the first and second waves in South Africa: a cohort study

Source: Lancet

Peer review article In South Africa, the second wave was associated with higher incidence of COVID-19, more rapid increase in admissions to hospital, and increased in-hospital mortality. Although some of...

thelancet.com

Mental disorders and risk of COVID-19-related mortality, hospitalisation, and intensive care unit admission: a systematic review and meta-analysis

Source: Lancet

Peer review article Pre-existing mental disorders, in particular psychotic and mood disorders, and exposure to antipsychotics and anxiolytics were associated with COVID-19 mortality in both crude and adjusted models. Although...

thelancet.com

Neurological manifestations of SARS-CoV-2 infection in hospitalised children and adolescents in the UK: a prospective national cohort study

Source: Lancet

Peer review article This study identified key differences between those with a primary neurological disorder versus those with PIMS-TS (an inflamatory syndrome). Compared with patients with a primary neurological disorder,...

thelancet.com

Global minimum estimates of children affected by COVID-19-associated orphanhood and deaths of caregivers: a modelling study

Source: Lancet

Peer review article Orphanhood and caregiver deaths are a hidden pandemic resulting from COVID-19-associated deaths. Accelerating equitable vaccine delivery is key to prevention. Psychosocial and economic support can help families...

thelancet.com

Immediate effect of the COVID-19 pandemic on patient health, health-care use, and behaviours: results from an international survey of people with rheumatic diseases

Source: Lancet

Peer review article People with rheumatic disease maintained therapy and followed public health advice to mitigate the risks of COVID-19. Substantial employment status changes occurred, with potential implications for health-care...

thelancet.com

Anosmia, ageusia, and other COVID-19-like symptoms in association with a positive SARS-CoV-2 test, across six national digital surveillance platforms: an observational study

Source: Lancet

Peer review article The strong association of anosmia (loss of smell) and ageusia (loss of taste) with self-reported positive SARS-CoV-2 test was consistently observed, supporting its validity as a reliable...

thelancet.com

Risk of acute myocardial infarction and ischaemic stroke following COVID-19 in Sweden: a self-controlled case series and matched cohort study

Source: Lancet

Peer review article Findings suggest that COVID-19 is a risk factor for acute myocardial infarction (heart attacks) and ischaemic stroke (the most common type of stroke). This indicates that acute...

bmj.com

Covid-19: Two thirds in India carry antibodies, while research suggests country’s death toll is 10 times official figure

Source: BMJ

India’s fourth “serosurvey” of the covid pandemic has found neutralising antibodies to the novel coronavirus in 67.6% of people aged over 6, suggesting that more than two in three people...

bmj.com

Covid-19: Indonesia becomes Asia’s new pandemic epicentre as delta variant spreads

Source: BMJ

The delta variant of covid-19 is causing an escalating crisis in Indonesia, two months after it swept through India. Indonesia’s case numbers have risen sharply for the past month and...

bmj.com

Covid-19: 1.5 million children have been orphaned by pandemic, study estimates

Source: BMJ

Covid-19 has not only killed more than four million people worldwide but has also left at least one million orphans, a study published in the Lancet has estimated. In England...

bmj.com

Covid-19: China stymies investigation into pandemic’s origins

Source: BMJ

Experts generally agree with that assessment that the virus was not created in the Wuhan facility, but some worry that it does not rule out the possibility of a wild...

cdc.gov

COVID-19 Science Update released: July 2, 2021 Edition 96

Source: US CDC

Report on 5 peer review articles Prevention efforts need to focus on highly impacted older age groups and also on Hispanic/Latino, non-Hispanic Black, non-Hispanic AI/AN, and non-Hispanic populations, where a...

cdc.gov

Post-COVID Conditions

Source: US CDC

Although most people with COVID-19 get better within weeks of illness, some people experience post-COVID conditions. Post-COVID conditions are a wide range of new, returning, or ongoing health problems people...

cdc.gov

COVID-19 Science Update released: July 9, 2021 Edition 97

Source: US CDC

Report on 8 peer review articles It is unknown how neutralising antibody production correlates with protection from infection. BNT162b2 (Pfizer-BioNTech) has been found to prevent symptomatic COVID-19 in persons ≥80...

cdc.gov

COVID-19 Science Update released: July 16, 2021 Edition 98

Source: US CDC

Report on 4 peer review articles Coincident with rising prevalence and transmission of the SARS-CoV-2 Delta variant, positive cases continue to increase in England, with younger populations experiencing the largest...

cdc.gov

What to Know About HIV and COVID-19

Source: US CDC

People with HIV may have concerns and questions about COVID-19, including the risk of serious illness and vaccine safety. CDC will continue to provide updated information as it becomes available.

cdc.gov

COVID-19 Science Update released: July 23, 2021 Edition 99

Source: US CDC

Report on 7 peer review articles The Black/White COVID-19 mortality ratio (in the US) has been declining and the driving force for the observed mortality convergence appears to be changes...

who.int

WHO warns that HIV infection increases risk of severe and critical COVID-19

Source: WHO

It found that the risk of developing severe or fatal COVID-19 was 30% greater in people living with HIV (PLHIV) compared to people without HIV infection. Underlying conditions such as...

afro.who.int

COVID-19 deaths in Africa surge more than 40% over previous week

Source: WHO Africa

COVID-19 cases have risen for eight straight weeks, topping 6 million on 13 July 2021. Over the past month, Africa recorded an additional 1 million cases. This is the shortest...

afro.who.int

COVID-19 widens routine immunization gaps in Africa

Source: WHO Africa

Around 7.7 million African children missed out on vital first doses of Diphtheria-Tetanus-Pertussis, Measles and Polio vaccines in 2020. The nearly 10% rise in missed vaccinations on the previous year...

Nigeria CDC

Confirmed Case of Delta Variant Detected in Nigeria

Source: 7/8/21

The Nigeria Centre for Disease Control (NCDC) has detected a confirmed case with the SARS-CoV-2 Delta variant, also known as lineage B.1.617.2. The variant was detected in a traveler to...

NEJM

SARS-CoV-2 Variants and Vaccines

Source: 7/8/21

Viral variants of concern may emerge with dangerous resistance to the immunity generated by the current vaccines to prevent coronavirus disease 2019 (Covid-19). Moreover, if some variants of concern have...

NICE

https://www.nice.org.uk/guidance/ng200

Source: 7/29/21

This guideline covers vaccine-induced immune thrombocytopenia and thrombosis (VITT - blood clotting events)), a syndrome which has been reported in rare cases after COVID-19 vaccination. VITT may also be called...

EU CDC

SARS-COV-2 Delta variant now dominant in much of the European Region and efforts must be reinforced to prevent transmission, warn WHO/Europe and ECDC

Source: 7/23/21

The SARS-COV-2 Delta variant of concern is spreading quickly across Europe and has now become the dominant strain across much of the region, according to new data.

Lancet

Neutralisation of SARS-CoV-2 lineage P.1 by antibodies elicited through natural SARS-CoV-2 infection or vaccination with an inactivated SARS-CoV-2 vaccine: an immunological study

Source: 7/8/21

Peer review article SARS-CoV-2 lineage P.1 (Gamma variant) might escape neutralisation by antibodies generated in response to polyclonal stimulation (where multiple types of white blood cell can target the same...

Lancet

Neurological manifestations of SARS-CoV-2 infection in hospitalised children and adolescents in the UK: a prospective national cohort study

Source: 7/14/21

Peer review article This study identified key differences between those with a primary neurological disorder versus those with PIMS-TS (an inflamatory syndrome). Compared with patients with a primary neurological disorder,...

Lancet

Difference in mortality among individuals admitted to hospital with COVID-19 during the first and second waves in South Africa: a cohort study

Source: 7/9/21

Peer review article In South Africa, the second wave was associated with higher incidence of COVID-19, more rapid increase in admissions to hospital, and increased in-hospital mortality. Although some of...

Lancet

Mental disorders and risk of COVID-19-related mortality, hospitalisation, and intensive care unit admission: a systematic review and meta-analysis

Source: 7/15/21

Peer review article Pre-existing mental disorders, in particular psychotic and mood disorders, and exposure to antipsychotics and anxiolytics were associated with COVID-19 mortality in both crude and adjusted models. Although...

Lancet

Global minimum estimates of children affected by COVID-19-associated orphanhood and deaths of caregivers: a modelling study

Source: 7/20/21

Peer review article Orphanhood and caregiver deaths are a hidden pandemic resulting from COVID-19-associated deaths. Accelerating equitable vaccine delivery is key to prevention. Psychosocial and economic support can help families...

Lancet

Anosmia, ageusia, and other COVID-19-like symptoms in association with a positive SARS-CoV-2 test, across six national digital surveillance platforms: an observational study

Source: 7/22/21

Peer review article The strong association of anosmia (loss of smell) and ageusia (loss of taste) with self-reported positive SARS-CoV-2 test was consistently observed, supporting its validity as a reliable...

Lancet

Immediate effect of the COVID-19 pandemic on patient health, health-care use, and behaviours: results from an international survey of people with rheumatic diseases

Source: 7/22/21

Peer review article People with rheumatic disease maintained therapy and followed public health advice to mitigate the risks of COVID-19. Substantial employment status changes occurred, with potential implications for health-care...

Lancet

Risk of acute myocardial infarction and ischaemic stroke following COVID-19 in Sweden: a self-controlled case series and matched cohort study

Source: 7/29/21

Peer review article Findings suggest that COVID-19 is a risk factor for acute myocardial infarction (heart attacks) and ischaemic stroke (the most common type of stroke). This indicates that acute...

BMJ

Covid-19: Indonesia becomes Asia’s new pandemic epicentre as delta variant spreads

Source: 7/16/21

The delta variant of covid-19 is causing an escalating crisis in Indonesia, two months after it swept through India. Indonesia’s case numbers have risen sharply for the past month and...

BMJ

Covid-19: 1.5 million children have been orphaned by pandemic, study estimates

Source: 7/22/21

Covid-19 has not only killed more than four million people worldwide but has also left at least one million orphans, a study published in the Lancet has estimated. In England...

BMJ

Covid-19: Two thirds in India carry antibodies, while research suggests country’s death toll is 10 times official figure

Source: 7/21/21

India’s fourth “serosurvey” of the covid pandemic has found neutralising antibodies to the novel coronavirus in 67.6% of people aged over 6, suggesting that more than two in three people...

BMJ

Covid-19: China stymies investigation into pandemic’s origins

Source: 7/27/21

Experts generally agree with that assessment that the virus was not created in the Wuhan facility, but some worry that it does not rule out the possibility of a wild...

US CDC

COVID-19 Science Update released: July 2, 2021 Edition 96

Source: 7/2/21

Report on 5 peer review articles Prevention efforts need to focus on highly impacted older age groups and also on Hispanic/Latino, non-Hispanic Black, non-Hispanic AI/AN, and non-Hispanic populations, where a...

US CDC

Post-COVID Conditions

Source: 7/12/21

Although most people with COVID-19 get better within weeks of illness, some people experience post-COVID conditions. Post-COVID conditions are a wide range of new, returning, or ongoing health problems people...

US CDC

COVID-19 Science Update released: July 9, 2021 Edition 97

Source: 7/9/21

Report on 8 peer review articles It is unknown how neutralising antibody production correlates with protection from infection. BNT162b2 (Pfizer-BioNTech) has been found to prevent symptomatic COVID-19 in persons ≥80...

US CDC

COVID-19 Science Update released: July 16, 2021 Edition 98

Source: 7/16/21

Report on 4 peer review articles Coincident with rising prevalence and transmission of the SARS-CoV-2 Delta variant, positive cases continue to increase in England, with younger populations experiencing the largest...

US CDC

What to Know About HIV and COVID-19

Source: 7/30/21

People with HIV may have concerns and questions about COVID-19, including the risk of serious illness and vaccine safety. CDC will continue to provide updated information as it becomes available.

US CDC

COVID-19 Science Update released: July 23, 2021 Edition 99

Source: 7/23/21

Report on 7 peer review articles The Black/White COVID-19 mortality ratio (in the US) has been declining and the driving force for the observed mortality convergence appears to be changes...

WHO

WHO warns that HIV infection increases risk of severe and critical COVID-19

Source: 7/15/21

It found that the risk of developing severe or fatal COVID-19 was 30% greater in people living with HIV (PLHIV) compared to people without HIV infection. Underlying conditions such as...

WHO Africa

COVID-19 deaths in Africa surge more than 40% over previous week

Source: 7/15/21

COVID-19 cases have risen for eight straight weeks, topping 6 million on 13 July 2021. Over the past month, Africa recorded an additional 1 million cases. This is the shortest...

WHO Africa

COVID-19 widens routine immunization gaps in Africa

Source: 7/29/21

Around 7.7 million African children missed out on vital first doses of Diphtheria-Tetanus-Pertussis, Measles and Polio vaccines in 2020. The nearly 10% rise in missed vaccinations on the previous year...

NEJM

COVID-19 Is Associated with Increased Vascular Risk

Source: 8/9/21

Report on peer review article This nationwide study provides evidence that COVID-19 is a risk factor for heart attack and stroke. We need to learn how long this risk persists...

NEJM

Does Diminished Nasopharyngeal Antiviral Immunity Precede Severe COVID-19?

Source: 8/9/21

Report on peer review article Certain people develop a very fast rate of viral growth in their noses. Finding out what causes this is important. In addition to enhancing our...

Lancet

Childhood obesity beyond COVID-19

Source: 8/1/21

Opinion piece As children return to schools, these institutions could play an even more important part in delivering healthy nutrition, and physical and food education. Importantly, there is an opportunity...

Lancet

Risk factors for COVID-19-related in-hospital mortality in a high HIV and tuberculosis prevalence setting in South Africa: a cohort study

Source: 8/4/21

Peer review article Individuals identified as being at high risk of COVID-19 in-hospital mortality (older individuals and those with chronic comorbidities and people with HIV, particularly those not on antiretrovirals)...

Lancet

Long Covid in adults discharged from UK hospitals after Covid-19: A prospective, multicentre cohort study using the ISARIC WHO Clinical Characterisation Protocol

Source: 8/5/21

Peer review article This study sought to establish the long-term effects of Covid-19 following hospitalisation. 55% of participants reported not feeling fully recovered. 93% reported persistent symptoms, with fatigue the...

Lancet

The foreseen loss of the battle against COVID-19 in South America: A foretold tragedy

Source: 8/4/21

Opinion piece In South America, strained and underfunded health systems, deep social inequalities and increasing poverty, slow vaccination rates and increased spread of new variants are leading to a surge...

Lancet

Mucormycosis after COVID-19 in a patient with diabetes

Source: 8/4/21

Case study of COVID-19 linked fungal infection. COVID-19 followed by mucormycosis carries a very high mortality rate and timely detection, antifungal therapy, and aggressive surgical debridement remain key factors in...

Lancet

Upregulation of pulmonary tissue factor, loss of thrombomodulin and immunothrombosis in SARS-CoV-2 infection

Source: 8/5/21

Peer review article SARS-CoV-2 infection is associated with clotting and complications on small blood vessels. The cause of clotting in the disease is incompletely understood. It appears there may be...

BMJ

Covid-19: Most symptomatic children recover within a week, study finds

Source: 8/4/21

Report on peer review article Most children who test positive for covid-19 and experience symptoms recover within a week, although a small proportion are unwell for more than four weeks,...

BMJ

Covid-19: Delta infections threaten herd immunity vaccine strategy

Source: 8/2/21

Epidemiologists are adjusting their expectations for the future course of the pandemic after data from a recent outbreak in Massachusetts in the US suggest that while vaccination remains highly protective...

US CDC

Animals and COVID-19

Source: 8/5/21

Based on the available information to date, the risk of animals spreading SARS-CoV-2, the virus that causes COVID-19, to people is considered to be low. We are still learning about...

US CDC

Delta Variant: What We Know About the Science

Source: 8/6/21

The Delta variant is highly contagious, nearly twice as contagious as previous variants. In two different studies from Canada and Scotland, patients infected with the Delta variant were more likely...

WHO Africa

Record weekly COVID-19 deaths in Africa

Source: 8/5/21

Weekly COVID-19 deaths in Africa reached a record peak in the week that ended on 1 August, marking the highest seven-day toll since the onset of the pandemic in the...

fullfact.org

Government modelling not proof of vaccine ‘genocide’

Source: Fullfact

Claim: A government document showing that 60-70% of Covid deaths over the summer will be among the vaccinated is proof that vaccines are intended for genocide. Verdict: False.

fullfact.org

Instagram post gets it wrong about Covid-19 vaccines and animal testing

Source: Fullfact

Claim: Covid-19 has a survival rate of 99.998%. Verdict: While there is no completely accurate statistic, based on the sheer number of people who died from Covid-19 we know the...

jwatch.org

Pinpointing the Infectiousness of SARS-CoV-2 and Its Alpha (B.1.1.7) Variant

Source: NEJM

The higher viral load seen in Alpha infected cases provides a virologic explanation for this variant's dominance; going forward, similar analytic data will be needed for the Delta variant as...

nejm.org

SARS-CoV-2 Variants and Vaccines

Source: NEJM

Viral variants of concern may emerge with dangerous resistance to the immunity generated by the current vaccines to prevent coronavirus disease 2019 (Covid-19).

ecdc.europa.eu

Threat Assessment Brief: Implications for the EU/EEA on the spread of the SARS-CoV-2 Delta (B.1.617.2) variant of concern

Source: EU CDC

The aim of this threat assessment brief is to assess potential public health implications of the spread of the SARS-CoV-2 Delta variant of concern for the European Union and European...

thelancet.com

Neuropsychiatric disorders and COVID-19

Source: Lancet

Three suggestions given regarding the neuropsychological effects of COVID-19.

thelancet.com

Neuropsychiatric disorders and COVID-19

Source: Lancet

Neuromuscular disorders after COVID-19 might have substantial implications for patient recovery and utilisation of physical rehabilitation healthcare resources.

thelancet.com

Invasive mould disease in fatal COVID-19: a systematic review of autopsies

Source: Lancet

Invasive mould disease (IMD) might affect up to a third of critically ill patients with COVID-19. Clinicians and pathologists alike should stay vigilant to the possibility of IMD as a...

thelancet.com

Mortality and critical care unit admission associated with the SARS-CoV-2 lineage B.1.1.7 in England: an observational cohort study

Source: Lancet

Patients with lineage B.1.1.7 (Alpha - UK) were at increased risk of CCU admission and 28-day death rate compared with patients with non-B.1.1.7 SARS-CoV-2. Our findings emphasise the importance of...

thelancet.com

Risk of hospitalisation associated with infection with SARS-CoV-2 lineage B.1.1.7 in Denmark: an observational cohort study

Source: Lancet

Infection with the Alpha variant (UK) was associated with an increased risk of hospitalisation compared with that of other lineages in an analysis adjusted for covariates.

bmj.com

Persistent pulmonary disease after acute covid-19

Source: BMJ

While persisting lung damage may be substantial for some, for many, morbidity and mortality after covid-19 are influenced most by pre-existing conditions, infection severity, and the extra-pulmonary complications of SARS-CoV-2.

bmj.com

Chronic fatigue syndrome and long covid: moving beyond the controversy

Source: BMJ

Many patients with “long” COVID are experiencing extreme fatigue, a situation that has re-polarised approaches to treatment and rehabilitation.

bmj.com

Covid-19: Cases of delta variant rise by 79%, but rate of growth slows

Source: BMJ

Public Health England said that the data showed there was a higher risk of hospital admission for patients with the delta variant compared with the alpha variant, but its analysis...

bmj.com

Covid-19: Third of people infected have long term symptoms

Source: BMJ

Around a third of people in England who developed covid-19 went on to experience long term symptoms sometimes called “long covid,” a UK study has found.

bmj.com

Covid-19: Hunger spreads and food prices soar amid pandemic, warns UN food agency

Source: BMJ

The number of people assessed as facing the imminent possibility of starvation without food assistance now stands at 41 million, up from 27 million in 2019, according to the joint...

cdc.gov

COVID-19 Science Update released: June 25, 2021 Edition 95

Source: US CDC

Report on 6 peer review articles and 4 pre-release peer review articles

cdc.gov

COVID-19 Science Update released: June 18, 2021 Edition 94

Source: US CDC

Report on 7 peer review articles and 1 pre-release peer review articles

cdc.gov

Symptoms of Depression, Anxiety, Post-Traumatic Stress Disorder, and Suicidal Ideation Among State, Tribal, Local, and Territorial Public Health Workers During the COVID-19 Pandemic — United States, March–April 2021

Source: US CDC

Implementing prevention and control practices that eliminate, reduce, and manage factors that cause or contribute to public health workers’ poor mental health might improve mental health outcomes during emergencies.

afro.who.int

Africa faces steepest COVID-19 surge yet

Source: WHO Africa

Africa is facing a fast-surging third wave of COVID-19 pandemic, with cases spreading more rapidly and projected to soon overtake the peak of the second wave the continent witnessed at...

jwatch.org

Long-Term Outcomes in Children with Pediatric Inflammatory Multisystem Syndrome

Source: NEJM

The 6 month outcomes of children with pediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 are reassuring, aside from the persistence of physical deconditioning and psychological effects.

jwatch.org

Detailing the Sequelae After Recovery from COVID-19

Source: NEJM

An editorialist notes that long COVID is putting undue strain on healthcare services, which had already been considerably burdened by the pandemic

thelancet.com

Persistence of SARS-CoV-2 RNA in lung tissue after mild COVID-19

Source: Lancet

Data on sputum, nasopharyngeal swabs, and bronchoalveolar lavage fluid indicate that prolonged detection of SARS-CoV-2 RNA is rare and limited to a few weeks. By contrast, SARS-CoV-2 RNA persisted in...

thelancet.com

From routine data collection to policy design: sex and gender both matter in COVID-19

Source: Lancet

Opinion piece: Pandemic responses that do not recognise the importance of sex and gender will always be less equitable and less effective.

thelancet.com

Alcohol-related harm during the COVID-19 pandemic

Source: Lancet

Opinion piece: It is vital that clinicians actively screen for and address alcohol misuse to ensure these patients have ready access to alcohol counselling and addiction treatments.

thelancet.com

Inflammatory biomarkers in COVID-19-associated multisystem inflammatory syndrome in children, Kawasaki disease, and macrophage activation syndrome: a cohort study

Source: Lancet

The findings show a syndrome causing multiple bodily systems to become inflamed in COVID-19 patients is distinguishable from Kawasaki disease.

thelancet.com

Clinical characteristics and risk factors for death among hospitalised children and adolescents with COVID-19 in Brazil: an analysis of a nationwide database

Source: Lancet

Death from COVID-19 was associated with age, indigenous ethnicity, poor geopolitical region, and pre-existing medical conditions.

cdc.gov

COVID-19 Science Update released: June 11, 2021 Edition 93

Source: US CDC

Report on 6 peer review articles and 4 pre-release peer review articles.

jwatch.org

Detailing the Sequelae After Recovery from COVID-19

Source: NEJM

An editorialist notes that long COVID is putting undue strain on healthcare services, which had already been considerably burdened by the pandemic

jwatch.org

Long-Term Outcomes in Children with Pediatric Inflammatory Multisystem Syndrome

Source: NEJM

The 6 month outcomes of children with pediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 are reassuring, aside from the persistence of physical deconditioning and psychological effects.

thelancet.com

Persistence of SARS-CoV-2 RNA in lung tissue after mild COVID-19

Source: Lancet

Data on sputum, nasopharyngeal swabs, and bronchoalveolar lavage fluid indicate that prolonged detection of SARS-CoV-2 RNA is rare and limited to a few weeks. By contrast, SARS-CoV-2 RNA persisted in...

thelancet.com

From routine data collection to policy design: sex and gender both matter in COVID-19

Source: Lancet

Opinion piece: Pandemic responses that do not recognise the importance of sex and gender will always be less equitable and less effective.

thelancet.com

Inflammatory biomarkers in COVID-19-associated multisystem inflammatory syndrome in children, Kawasaki disease, and macrophage activation syndrome: a cohort study

Source: Lancet

The findings show a syndrome causing multiple bodily systems to become inflamed in COVID-19 patients is distinguishable from Kawasaki disease.

thelancet.com

Alcohol-related harm during the COVID-19 pandemic

Source: Lancet

Opinion piece: It is vital that clinicians actively screen for and address alcohol misuse to ensure these patients have ready access to alcohol counselling and addiction treatments.

thelancet.com

Clinical characteristics and risk factors for death among hospitalised children and adolescents with COVID-19 in Brazil: an analysis of a nationwide database

Source: Lancet

Death from COVID-19 was associated with age, indigenous ethnicity, poor geopolitical region, and pre-existing medical conditions.

cdc.gov

COVID-19 Science Update released: June 11, 2021 Edition 93

Source: US CDC

Report on 6 peer review articles and 4 pre-release peer review articles.

jwatch.org

Epidemiology of Long-Term COVID-19 Symptoms

Source: NEJM

This systematic analysis really constitutes more of a large case series than a robust meta-analysis because of the highly heterogeneous nature of the original studies.

nejm.org

Thrombosis and Thrombocytopenia after ChAdOx1 nCoV-19 Vaccination

Source: NEJM

Report on 5 patients who presented blood clotting issues after the Ad26.COV2 J&J vaccine. The patients were health care workers who were 32 to 54 years of age.

jwatch.org

COVID-19 Myocarditis in Athletes

Source: NEJM

This study is limited by its focus on a selected group of young, competitive athletes, but it still has value in giving us a ballpark estimate of COVID-19 myocarditis incidence.

thelancet.com

Co-infections, secondary infections, and antimicrobial use in patients hospitalised with COVID-19 during the first pandemic wave from the ISARIC WHO CCP-UK study: a multicentre, prospective cohort study

Source: Lancet

The frequency and nature of antimicrobial use are concerning as this could give rise to future strains being antibiotic-resistant.

thelancet.com

A lost generation? COVID-19 and adolescent mental health

Source: Lancet

Future efforts need to address the prepandemic as well as the pandemic-related increasing trend of mental health problems in the adolescent population.

thelancet.com

COVID-19 reinfections in The Gambia by phylogenetically distinct SARS-CoV-2 variants—first two confirmed events in west Africa

Source: Lancet

There have been two confirmed reinfections among healthy Gambian individuals aged 31 years and 36 years, with a time lag of 5 months and 6 months, respectively.

thelancet.com

Rising incidence of mucormycosis in patients with COVID-19: another challenge for India amidst the second wave?

Source: Lancet

Another imminent threat has emerged as a challenge to India in the form of coronavirus disease-associated mucormycosis. It is a rare but potentially fatal infection if inadequately treated.

thelancet.com

Bottom-up citizen engagement for health emergency and disaster risk management: directions since COVID-19

Source: Lancet

Many communities have struggled to establish inclusive and relevant governance channels that include their unique needs and perspectives.

thelancet.com

Need for and use of contraception by women before and during COVID-19 in four sub-Saharan African geographies: results from population-based national or regional cohort surveys

Source: Lancet

Findings do not support the anticipated deleterious effect of COVID-19 on access to and use of contraceptive services by women in the earliest stages of the pandemic.

bmj.com

Covid-19: Delta variant is now UK’s most dominant strain and spreading through schools

Source: BMJ

The delta covid-19 variant, which was first detected in India, has overtaken the alpha variant, or UK variant, to make it the most dominant strain circulating in the UK.

bmj.com

Covid 19: How harm reduction advocates and the tobacco industry capitalized on the pandemic to promote nicotine

Source: BMJ

Scientific papers suggesting that smokers are less likely to fall ill with covid-19 are being discredited as links to the tobacco industry are revealed.

cdc.gov

COVID-19 Science Update released: June 4, 2021 Edition 92

Source: US CDC

Report on 6 peer review articles and 3 pre-release peer review articles.

jwatch.org

SARS-CoV-2 Seropositivity Is Not Associated with Low Vitamin D Levels

Source: NEMJ

These results add to the now generally accepted belief that vitamin D levels are not associated with risk for SARS-CoV-2 infection.

thelancet.com

Systemic lupus erythematosus does not prevent antibody responses to SARS-CoV-2

Source: Lancet

It remains to be confirmed whether these SARS-CoV-2 antibodies are protective in patients with Systemic lupus erythematosus (SLE).

thelancet.com

Changes in the incidence of invasive disease due to Streptococcus pneumoniae, Haemophilus influenzae, and Neisseria meningitidis during the COVID-19 pandemic in 26 countries and territories in the Invasive Respiratory Infection Surveillance Initiative: a prospective analysis of surveillance data

Source: Lancet

Peer review article The introduction of COVID-19 containment policies and public information campaigns likely reduced transmission of S pneumoniae, H influenzae, and N meningitidis, leading to a significant reduction in...

thelancet.com

COVID-19 and global mental health

Source: Lancet

The review documents widespread innovation in low and middle-income countries to increase mental illness detection and maintain treatment during lockdowns.

thelancet.com

HIV in the age of COVID-19

Source: Lancet

The predicted extra 500,000 deaths in sub-Saharan Africa might not have come to pass, but the COVID-19 pandemic is far from over.

cdc.gov

Basics of COVID-19

Source: US CDC

This page provides an overview of the COVID19 disease with a high quality animated video explainer

cdc.gov

Clinical Considerations: Myocarditis and Pericarditis after Receipt of mRNA COVID-19 Vaccines Among Adolescents and Young Adults

Source: US CDC

Since April 2021, increased cases of myocarditis and pericarditis have been reported in the US after mRNA COVID-19 vaccination, particularly in adolescents and young adults.

cdc.gov

COVID-19 Science Update released: May 28, 2021 Edition 91

Source: US CDC

Report on 8 peer review articles and 2 pre-release peer review articles.

poynter.org

What we know and don’t know about the origins of COVID-19

Source:

Much uncertainty remains about the origins of COVID-19. Scientists who have studied the coronavirus have generally concluded that it resembles naturally occurring viruses.

fullfact.org

The risk of dying from a Covid vaccine is lower than 1 in 31,000

Source: Full Fact

Claim: The risk of a child dying of Covid-19 is around one in 3.5 million. Verdict: The risk of a child dying of Covid is very low.

snopes.com

Did Fauci Fund ‘Gain of Function’ Research, Thereby Causing COVID-19 Pandemic?

Source:

Claim: NIH Director Anthony Fauci helped fund the gain of function research at a facility in Wuhan, China, and that research ultimately led to the COVID-19 pandemic. Verdict: Unproven.

jwatch.org

Likelihood of Thromboembolic Events After Receipt of the Oxford/AstraZeneca Vaccine

Source: NEJM

This study confirms the excess risk for thrombotic events among Oxford/AstraZeneca vaccine recipients, especially for cerebral venous thrombosis.

ecdc.europa.eu

Public health impact of SARS-CoV-2 variants of concern: scoping review protocol

Source: EU CDC

Several SARS-CoV-2 variants have been identified. This article updates both the variants of interest (VOI) and those of concern (VOC)

thelancet.com

Vascular mechanisms and manifestations of COVID-19

Source: Lancet

A remarkable finding in patients with severe Covid-19 is coagulation abnormalities (blood clotting issues), which have been associated with respiratory deterioration and death.

thelancet.com

What chikungunya teaches us about COVID-19

Source: Lancet

There are calls for urgent research on long COVID to avoid having millions of adults with long COVID left behind, with an inestimable social and economic impact.

thelancet.com

SARS-CoV-2 B.1.1.7 and B.1.351 spike variants bind human ACE2 with increased affinity

Source: Lancet

Efforts have uncovered SARS-CoV-2 variants with mutations in the viral spike glycoprotein, which binds the human angiotensin-converting enzyme 2 (ACE2) receptor to facilitate viral entry.

thelancet.com

Psychosis and COVID-19: is it time to pre-emptively revise advanced directives?

Source: Lancet

Dynamic, early decisions for treatment (advance directives) in line with the rapidly evolving pandemic situation will add more value to patient with psychosis' autonomy.

thelancet.com

Gendered effects of COVID-19 on young girls in regions of conflict

Source: Lancet

In settings of violent conflict, young girls are about 25 times more likely to be out of school than their male counterparts, and the pandemic appears to have exacerbated this...

thelancet.com

Seroprevalence of anti-SARS-CoV-2 antibodies in Iquitos, Peru in July and August, 2020: a population-based study

Source: Lancet

After the first epidemic peak, Iquitos had one of the highest rates of seroprevalence of anti-SARS-CoV-2 antibodies worldwide. Nevertheless, the city experienced a second wave, which has shown higher transmissibility...

thelancet.com

Patient care and clinical outcomes for patients with COVID-19 infection admitted to African high-care or intensive care units (ACCCOS): a multicentre, prospective, observational cohort study

Source: Lancet

Mortality in critically ill patients with COVID-19 is higher in African countries than reported from studies done in Asia, Europe, North America, and South America.

blogs.bmj.com

Covid-19: What should we do about B.1.617.2? A classic case of decision making under uncertainty

Source: BMJ

Compared to the dominant UK variant, we know that the Indian variant is very likely to be more transmissible and that it might be better able to transmit between people...

who.int

New international expert panel to address the emergence and spread of zoonotic diseases

Source: WHO

International organizations have come together to launch a new One Health High-Level Expert Panel to improve understanding of how diseases with the potential to trigger pandemics emerge and spread.

fullfact.org

It’s not clear whether bald people get more ill with Covid-19

Source: Full Fact

Being older raises the risk of severe Covid-19, but based on the research we have so far, it is not yet clear whether baldness itself has any effect.

jwatch.org

Toward Defining an Immune Correlate of Protection Against SARS-CoV-2

Source: NEJM

Report on peer review article This study confirms that positive baseline anti-SARS-CoV-2 antibody status is associated with a lower risk for subsequent SARS-CoV-2 infection.

jwatch.org

Second Presentations of COVID-19 Due to Non–Variant-of-Concern Strains

Source: NEJM

This report provides the best evidence yet that reinfection can occur in apparently normal hosts and that the reinfecting virus may be similar, if not identical, to the original SARS-CoV-2.

ecdc.europa.eu

SARS-CoV-2 variants of concern as of 24 May 2021

Source: EU CDC

ECDC regularly assesses new evidence on variants detected through epidemic intelligence, rules-based genomic variant screening, or other scientific sources.

thelancet.com

Post-acute effects of SARS-CoV-2 infection in individuals not requiring hospital admission: a Danish population-based cohort study

Source: The Lancet

Peer review article The absolute risk of severe post-acute complications after SARS-CoV-2 infection not requiring hospital admission is low. However, increases in visits to general practitioners and outpatient hospital visits...

thelancet.com

India’s COVID-19 crisis: a call for international action

Source: The Lancet

With the exponential growth and without mitigation, estimates suggest India could reach more than 1 million COVID-19 cases per day with over 1 million cumulative COVID-19 deaths by Aug 1,...

nhs.uk

Long-term effects of coronavirus (long COVID)

Source: NHS

Some people’s symptoms of COVID-19 can last longer.The chances of having long-term symptoms do not seem to be linked to how ill you are when you first get COVID-19.

cdc.gov

COVID-19 Science Update released: May 14, 2021 Edition 89

Source: US CDC

Report on 3 peer review articles on agricultural labour and food supply, the rapid evolution of SARS-Cov-2 mutations and evidence of Pfizer vaccine effectiveness on the South African variants.

jwatch.org

The Emotional Toll of COVID-19 During Pregnancy

Source: NEJM

Poor mental health during pregnancy affects not only the mother but also her child.

jwatch.org

The Burden of COVID-19 in Pregnant Women and Their Newborns

Source: NEJM

The increased maternal and neonatal risks associated with COVID-19 during pregnancy are delineated in this convincing multinational study. The findings argue strongly for vaccination and continued health measures to prevent...

thelancet.com

An integrated understanding of long-term sequelae after acute COVID-19

Source: The Lancet

Each piece of information increases knowledge but we need to agree on common methodologies, generate robust data, and improve our capacity to share, absorb, and process high volumes of research...

thelancet.com

The COVID-19 puzzle: deciphering pathophysiology and phenotypes of a new disease entity

Source: The Lancet

An overview of current evidence regarding immuno-inflammatory reactions induced by SARS-CoV-2 and subsequent organ-based consequences suggests several conclusions: i) after infecting the upper respiratory tract, it is capable of subsequently...

thelancet.com

Sex and age differences in the incidence of acute myocardial infarction during the COVID-19 pandemic in a Swedish health-care region without lockdown: a retrospective cohort study

Source: The Lancet

The incidence of acute myocardial infarction (heart attack) decreased predominantly among women aged 70 years or older during the COVID-19 pandemic.

bmj.com

Covid-19: Uptake of testing does not reflect chances of positive test, study finds

Source: BMJ

“Having certain underlying health conditions, like asthma and chronic obstructive pulmonary diseases including emphysema and chronic bronchitis, increased the likelihood of being tested for SARS-CoV-2 even though those conditions were...

cdc.gov

COVID-19 Science Update released: May 7, 2021 Edition 88

Source: US CDC

Report on 3 peer review articles.

ecdc.europa.eu

SARS-CoV-2 variants of concern pose a higher risk for hospitalisation and intensive care admission

Source: EU CDC

Since the discovery of SARS-CoV-2, three variants of concern (VOC), first identified in the United Kingdom (B.1.1.7), South Africa (B.1.351), and Brazil (P.1), have been associated with higher transmissibility and...

thelancet.com

COVID-19-associated coagulopathy and antithrombotic agents—lessons after 1 year

Source: The Lancet

COVID-19 is associated with a high incidence of thrombotic (blood-clotting) complications, which can be explained by the complex and unique interplay between coronaviruses and endothelial cells (those which line blood...

thelancet.com

Cancer and COVID-19 vaccines: a complex global picture

Source: The Lancet

Patients with cancer can be at high risk of severe COVID-19 due to their age, disease, cancer treatment, and medical co-morbidities.

thelancet.com

COVID-19 in patients with rheumatic disease: finally, a denominator

Source: The Lancet

The timing of therapy in COVID-19 is undoubtedly crucial, but outstanding questions include whether certain therapies for rheumatic disease, such as interleukin-6 and Janus kinase 1 inhibition should be used...

thelancet.com

New insights into the association between body-mass index and severe COVID-19

Source: The Lancet

Obesity was one of a number of factors rapidly identified as being associated with COVID-19-associated mortality.

thelancet.com

SARS-CoV-2 immunity and HIV infection: total recall?

Source: The Lancet

People with HIV, even those on antiretroviral therapy with controlled viral load, might be at risk of lower response to COVID-19 immunisation.

thelancet.com

Overview of SARS-CoV-2 infection in adults living with HIV

Source: The Lancet

Recent large studies suggest that people living with HIV might be more severely ill than those who are HIV-negative.

thelancet.com

Associations between body-mass index and COVID-19 severity in 6·9 million people in England: a prospective, community-based, cohort study

Source: The Lancet

Based on a UK study of obesity and COVID-19, at a BMI of more than 23 kg/m2, there was an increase in the risk of severe COVID-19 leading to admission...

thelancet.com

SARS-CoV-2 seroprevalence, and IgG concentration and pseudovirus neutralising antibody titres after infection, compared by HIV status: a matched case-control observational study

Source: The Lancet

Although fewer infections were detected by SARS-CoV-2 IgG (antibody) testing among people living with HIV than among those without HIV, people with HIV had more cases of severe COVID-19.

bmj.com

Covid-19: Most people admitted to hospital after vaccination were infected before immunity could develop, research shows

Source: BMJ

This highlightes the importance of maintaining social distancing and understanding that immunity develops over time, researchers have said

jwatch.org

COVID-19: Reinfection Risk / Bamlanivimab Authorization Revoked

Source: NEJM

A study in The Lancet Respiratory Medicine helps characterize the risk for SARS-CoV-2 reinfection in a close contact setting.

jwatch.org

High Incidence of Neurological and Psychiatric Illness After COVID-19

Source: NEJM

This large study demonstrates that various neurological or psychiatric disorders develop with a relatively high incidence in the 6 months following acute COVID-19.

jwatch.org

Mild COVID-19 Is Not Necessarily Benign

Source: NEJM

Understanding the way the disease affects people over a longer time period and potential therapeutic interventions for this condition is urgently needed.

nejm.org

Vaccine Breakthrough Infections with SARS-CoV-2 Variants

Source: NEJM

2 women out of a cohort of 417 persons who had received the second dose of Pfizer–BioNTech or Moderna vaccine identified with vaccine breakthrough infection.

thelancet.com

Post-acute COVID-19 outcomes in children with mild and asymptomatic disease

Source: Lancet

Data on the long-term effects of COVID-19 in children and adolescents are needed, and should ideally be nationally representative and include broader demographics.

thelancet.com

Are older people with disabilities neglected in the COVID-19 pandemic?

Source: Lancet

The exclusions of people with disabilities are social choices, not inevitable consequences of a health condition, and they are not new. 

thelancet.com

Mental health and social interactions of older people with physical disabilities in England during the COVID-19 pandemic: a longitudinal cohort study

Source: Lancet

People with a physical disability might be at particular risk for emotional distress, poor quality of life, and low wellbeing during COVID-19 pandemic.

thelancet.com

A conceptual framework to accelerate the clinical impact of evolving research into long COVID

Source: Lancet

An international survey of individuals with long COVID reported a wide range of symptoms that persisted for months and resulted in substantial disability.

blogs.bmj.com

Covid-19 new variants—known unknowns

Source: BMJ

The BMJ hosted a webinar on new variants, discussed what these are, where they come from, and what they might do, as well as what we know about how particular...

bmj.com

Covid-19: Spike in cases in Chile is blamed on people mixing after first vaccine shot

Source: BMJ

Cases of the COVID-19 are surging in Chile despite the country having one of the most successful vaccine rollouts in the world.

bmj.com

Covid-19: What do we know about airborne transmission of SARS-CoV-2?

Source: BMJ

UK advice states that COVID-19 spreads “through the air by droplets and smaller aerosols”. Infectious particles can “remain suspended in the air for some time indoors, especially if there is...

nejm.org

Serum Neutralizing Activity Elicited by mRNA-1273 Vaccine

Source: NEJM

Protection conferred by the mRNA-1273 (Moderna) vaccine against the P.1 (Brazilian), B.1.427/B.1.429 (Californian), and B.1.351 (South African) variants remains to be determined.

thelancet.com

Monitoring differences between the SARS-CoV-2 B.1.1.7 variant and other lineages

Source: The Lancet

Research monitoring the differences between the B.1.1.7 (UK) variant and other lineages produced results indicating no link between B.1.1.7 prevalence and the type or frequency of symptoms reported by users....

thelancet.com

Changes in symptomatology, reinfection, and transmissibility associated with the SARS-CoV-2 variant B.1.1.7: an ecological study

Source: The Lancet

This paper aims to investigate whether increases in the proportion of infections with SARS-CoV-2 variant B.1.1.7 are associated with differences in symptoms or disease course, reinfection rates, or transmissibility.

thelancet.com

Lack of detail in population-level data impedes analysis of SARS-CoV-2 variants of concern and clinical outcomes

Source: The Lancet

Genetic drift and selection pressures (in particular with passive antibody treatments and vaccination) will continue to engender changes in SARS-CoV-2 and might result in the emergence of variants of high...

thelancet.com

Genomic characteristics and clinical effect of the emergent SARS-CoV-2 B.1.1.7 lineage in London, UK: a whole-genome sequencing and hospital-based cohort study

Source: The Lancet

A paper describing the emergence of the B.1.1.7 (UK) variant of COVID-19, including its key characteristics and clinical severity.

thelancet.com

SARS-CoV-2 incidence and vaccine escape

Source: The Lancet

Reducing cases is not only beneficial for decreasing the pressure on health-care systems, but also for lowering the vaccine escape risk.

thelancet.com

Lowering SARS-CoV-2 viral load might affect transmission but not disease severity in secondary cases

Source: The Lancet

While reducing the amount of virus circulating in and between individuals might be a key strategy to limit SARS-CoV-2 spread, on the basis of the existing evidence, it seems unlikely...

thelancet.com

Pulmonary embolism and thrombocytopenia following ChAdOx1 vaccination

Source: The Lancet

A 51-year-old woman attended our emergency department with a 3-day history of dyspnoea, fatigue, and cough and was found to have severe thrombocytopenia (abnormally low level of platelets. 11 days...

thelancet.com

Mounting evidence of impaired viral control in severe COVID-19

Source: The Lancet

These findings suggest that the virus is a key driver of pathogenesis (how the disease develops) in severe COVID-19. Some immunological signatures denote an impaired ability to control viral replication...

thelancet.com

Suicide trends in the early months of the COVID-19 pandemic: an interrupted time-series analysis of preliminary data from 21 countries

Source: The Lancet

In high-income and upper-middle-income countries, suicide numbers have remained largely unchanged or declined in the early months of the pandemic compared with the expected levels based on the pre-pandemic period.

thelancet.com

SARS-CoV-2 seropositivity and subsequent infection risk in healthy young adults: a prospective cohort study

Source: The Lancet

Young adults who had tested positive for SARS-CoV-2 had about one-fifth the risk of subsequent infection compared with those who had not. Although antibodies induced by initial infection are largely...

bmj.com

Covid-19 has redefined airborne transmission

Source: BMJ

People infected with SARS-CoV-2 produce many small respiratory particles laden with virus as they exhale. Some of these will be inhaled almost immediately by those within a typical conversational “short...

fullfact.org

False death figures go viral

Source: FullFact

Claim: Up to week 47 of 2020, there were only 511,883 deaths in England and Wales, 20,000 fewer than the number of deaths in 2019. VERDICT False. Up to and...

fullfact.org

Covid-19 survival rate is not 99.991% for under 60s

Source: FullFact

Claim: According to NHS data, as of 21st January there have been 4,717 COVID-19 deaths of people between the ages of 0-59 in the UK. Verdict:  This is not true....

fullfact.org

Study doesn’t say most vapers are 17% more likely to transmit Covid

Source: FullFact

Claim: Vapers with COVID-19 are up to 17% more likely to transmit the virus. Verdict: The study found this may be the case in a small minority of vapers. However,...

jwatch.org

COVID-19: Dementia as Risk Factor / SARS-CoV-2 Origin?

Source: NEJM

Report on Research article Dementia as risk factor: Adults with dementia have twice the risk for COVID-19 as those without dementia, The team says it's "extremely unlikely" that it resulted...

thelancet.com

Genomic-informed pathogen surveillance in Africa: opportunities and challenges

Source: The Lancet

Opinion piece Monitoring, evaluation, and sustainability frameworks will be needed to assess the added value of NGS (next-generation sequencing - equipment with the ability for high pathogen resolution at increasingly...

thelancet.com

Effect of the new SARS-CoV-2 variant B.1.1.7 on children and young people

Source: The Lancet

Research article Early second wave data (in the UK) show that the number of children and young people being admitted to hospital might be due to the higher prevalence of...

thelancet.com

Association between Clinical Frailty Scale score and hospital mortality in adult patients with COVID-19 (COMET): an international, multicentre, retrospective, observational cohort study

Source: The Lancet

Treatment decisions are regularly based on patients’ degree of frailty measured by the Clinical Frailty Scale (CFS).  This study shows  that frail patients of all ages admitted to hospital with...

thelancet.com

SARS-CoV-2 transmission among children and staff in daycare centres during a nationwide lockdown in France: a cross-sectional, multicentre, seroprevalence study

Source: The Lancet

Research article The extent to which very young children contribute to the transmission of SARS-CoV-2 is unclear. On the basis of these findings, there is no evidence for daycare centres...

thelancet.com

CovMT: an interactive SARS-CoV-2 mutation tracker, with a focus on critical variants

Source: The Lancet

Research article It is vital to keep track of mutations in the genome of SARS-CoV-2, especially in the spike protein's receptor binding domain (RBD) region, which could potentially impact disease...

bmj.com

Covid-19: Is Manaus the final nail in the coffin for natural herd immunity?

Source: BMJ

Opinion piece “Manaus [a town in Brazil] shows that pursuing herd immunity through natural infection is not a guarantee. And second, even if we could reach it, hundreds of thousands...

bmj.com

Poverty, health, and covid-19

Source: BMJ

Opinion piece COVID-19 does not strike at random—mortality is much higher in elderly people, poorer groups, and ethnic minorities, and its economic effect is also unevenly distributed across the population....

bmj.com

Covid-19: More young children are being infected in Israel and Italy, emerging data suggest

Source: BMJ

Opinion piece Experts have warned that schools must be reopened with caution, amid emerging evidence from Israel and Italy that more young children are being infected with new variants of...

cdc.gov

COVID-19 Science Update released: February 12, 2021 Edition 76

Source: US CDC

A useful roundup of scientific information over the last week, newly aligned with the CDC science agenda. Topics covered include peer-reviewed and pre-release publications on; Natural History of SARS-CoV-2 Infection,...

afro.who.int

Rising mortality as Africa marks one year of COVID-19

Source: WHO Africa

Over 22 300 deaths were reported in Africa in the last 28 days, compared with nearly 16 000 deaths in the previous 28 days. The continent is expected to reach...

jwatch.org

COVID-19: Eye Abnormalities / Pulse Oximetry Accuracy & Skin Pigmentation

Source: NEJM

Comment on pre-release Researchers studied nearly 130 patients hospitalized with severe COVID-19 who had undergone brain MRI. Some 7% of patients had one or more nodules in the light receptor...

jwatch.org

COVID-19: U.S. Life Expectancy Drops / Global Years of Life Lost

Source: NEJM

Comment on pre-release Males had a larger decline in life expectancy, falling from 76.3 to 75.1.  By race, non-Hispanic Black people saw the largest drop, losing 2.7 years of life...

ecdc.europa.eu

Risk assessment: SARS-CoV-2 – increased circulation of variants of concern and vaccine rollout in the EU/EEA, 14th update

Source: EU CDC

This risk assessment provides an overall update on the COVID-19 situation in the EU/EEA, including latest data on the situation with SARS-CoV-2 variants of concern covered by previous targeted risk...

thelancet.com

Patient factors and temporal trends associated with COVID-19 in-hospital mortality in England: an observational study using administrative data

Source: The Lancet

Peer reviewed article 91 541 adult patients with COVID-19 were discharged during the study period, among which 28 200 (30·8%) in-hospital deaths occurred. In this model, significant predictors of in-hospital death included...

thelancet.com

Challenges in interpreting SARS-CoV-2 serological results in African countries

Source: The Lancet

Opinion piece The spread of the virus is probably wider than the numbers reported by official surveillance systems that are based on PCR results.  Serology tests detect antibodies against SARS-CoV-2,...

thelancet.com

Tuberculosis preventive therapy for children and adolescents: an emergency response to the COVID-19 pandemic

Source: The Lancet

COVID-19, the clinical syndrome caused by SARS-CoV-2, has caused a tremendous burden of global morbidity and mortality. COVID-19 is predicted to have a devastating impact on other global infections, most...

bmj.com

Covid-19 will become endemic but with decreased potency over time, scientists believe

Source: BMJ

Opinion piece The SARS-CoV-2 coronavirus will not be eradicated but will become endemic, continuing to circulate in pockets of the global population for years to come and causing outbreaks in...

bmj.com

Covid-19: Is vaccination roll out reducing cases and deaths in the UK?

Source: BMJ

Opinion piece Experts agree that although signs are encouraging better data are needed.  Duncan Robertson, an analyst from Loughborough University’s School of Business and Economics,  said, “The vaccination rollout data...

blogs.bmj.com

What makes new variants of SARS-CoV-2 concerning is not where they come from, but the mutations they contain

Source: BMJ

Opinion piece In the past three months global attention has turned to the discovery and relative global health risks of new variants of the SARS-CoV-2 virus. It is possible, maybe...

bmj.com

Covid-19 deaths in Africa: prospective systematic postmortem surveillance study

Source: BMJ

Peer reviewed paper Contrary to expectations, deaths with COVID-19 were common in Lusaka.  Most occurred in the community, where testing capacity is lacking.

nhs.uk

Long-term effects of coronavirus (long COVID)

Source: NHS

For some people, COVID-19 can cause symptoms that last weeks or months after the infection has gone. This is sometimes called post-COVID-19 syndrome or "long COVID".

cdc.gov

Detection of B.1.351 SARS-CoV-2 Variant Strain — Zambia, December 2020

Source: US CDC

Pre-release paper Expanding capacity for genetic epidemiology in Africa will help strengthen surveillance for the B.1.351 variant as well as early detection of emerging variants that might affect the implementation...

cdc.gov

COVID-19 Science Update released: February 19, 2021 Edition 77

Source: US CDC

A summary of pre-release peer reviewed medical papers from the last week. From the Office of the Chief Medical Officer, CDC COVID-19 Response, and the CDC Library, Atlanta GA intended...

jwatch.org

Secondary Infections in Patients with Severe COVID-19

Source: NEJM

Report on peer reviewed article Although few patients with COVID-19 also suffer from co-infections at hospital admission, bacterial or fungal infections appear to be quite common in critically ill patients...

jwatch.org

COVID-19: Blood Type A / Increased Transmissibility of B.1.1.7

Source: NEJM

NEJM Journal Watch highlighted further evidence linking increased chances of infection for people with the A blood group. A study estimates that the SARS-CoV-2 variant known as B.1.1.7, which was...

jwatch.org

Guillain-Barré Syndrome and COVID-19: Causation or Coincidence

Source: NEJM

A retrospective national epidemiologic study does not support a causal association between COVID-19 and Guillain-Barré Syndrome

thelancet.com

Non-communicable disease, sociodemographic factors, and risk of death from infection: a UK Biobank observational cohort study

Source: The Lancet

Several noncommunicable diseases (NCD) are associated with an increased risk of infection death, suggesting that some of the  reported associations with COVID-19 mortality might be non-specific. Only a subset of...

thelancet.com

Clinical characteristics and mortality associated with COVID-19 in Jakarta, Indonesia: A hospital-based retrospective cohort study

Source: The Lancet

Peer review article Overall in-hospital mortality associated with COVID-19 in Jakarta was lower than reported in high-income countries, probably due to younger age distribution and fewer comorbidities. Deaths occurred across...

thelancet.com

Multisystem inflammatory syndrome in a neonate, temporally associated with prenatal exposure to SARS-CoV-2: a case report

Source: The Lancet

Peer review article With pregnant women, globally becoming more vulnerable to COVID-19 exposure because of relaxation of restrictions and setting in of pandemic fatigue, protecting the maternal–fetal from SARS-CoV-2 through...

thelancet.com

Young person with long COVID after mild disease

Source: The Lancet

Opinion piece Highlighting the prevalence of long covid symptoms for people who contracted SARS-CoV-2 but only showed mild symptoms.

thelancet.com

Risk of adverse outcomes in patients with underlying respiratory conditions admitted to hospital with COVID-19: a national, multicentre prospective cohort study using the ISARIC WHO Clinical Characterisation Protocol UK

Source: The Lancet

Peer review article Underlying respiratory conditions are common in patients admitted to hospital with COVID-19. Regardless of the severity of symptoms at admission and comorbidities, patients with asthma and those...

thelancet.com

Metabolic health: a priority for the post-pandemic era

Source: The Lancet

The ongoing COVID-19 pandemic has highlighted the underlying poor metabolic health in our society, with metabolic diseases associated with COVID-19 severity and worse outcomes. A recently published comparative risk assessment...

bmj.com

Covid-19: Highest death rates seen in countries with most overweight populations

Source: BMJ

Taking data from over 160 countries, the report found linear correlations between a country’s COVID-19 mortality and the proportion of adults that are overweight. There is not a single example...

afro.who.int

Fewer COVID-19 cases among women in Africa: WHO analysis

Source: WHO Africa

Women account for a slightly smaller proportion of COVID-19 infections and deaths compared with men, a preliminary analysis by the World Health Organization (WHO) in 28 African countries shows. The...

jwatch.org

How Do Children Who Have MIS-C Compare with Those Who Have Severe Acute COVID-19?

Source: NEJM

Report on peer review article Although children become infected with SARS-CoV-2 at lower rates and experience milder symptoms than adults, a multisystem inflammatory syndrome in children (MIS-C) has been described...

jwatch.org

COVID-19: Higher Mortality with B.1.1.7 Variant / Acute Kidney Injury / Bamlanivimab + Etesevimab

Source: NEJM

Report on peer review article A study on the increased risk to patients already suffering from kidney disease, the higher mortality rates caused by the B1.1.7 variant and the effective...

jwatch.org

Our Recent Coverage of COVID-19

Source: NEJM

NEJM Journal Watch’s weekly summaries, commentary, and news on the pandemic. This week NEJM covered COVID-19–related topics including SARS-CoV-2 transmission in schools, SOFA scores and mortality, tocilizumab for severe disease,...

jwatch.org

Study Highlights COVID-19 Risks for Overweight, Obese Adults

Source: NEJM

Report on peer review article The finding that risk for severe COVID-19–associated illness increases with higher BMI suggests that progressively intensive management of COVID-19 might be needed for patients with...

thelancet.com

Patients with gout: an under-recognised group at high risk of COVID-19

Source: The Lancet

Opinion piece When patients with gout are not taking immunosuppressants, their comorbidities mean that they have among the highest risk of poor COVID-19-related outcomes of all patients with rheumatic diseases.

thelancet.com

Addressing fundamental questions on MIS-C

Source: The Lancet

Opinion piece The ongoing emergence and rapid dissemination of knowledge around multisystem inflammatory syndrome in children (MIS-C) is incredibly important for clinical teams around the world to treat their patients...

thelancet.com

The impact of SARS-CoV-2 variants on IBD management

Source: The Lancet

Opinion piece The COVID-19 pandemic has revealed several challenges in inflammatory bowel disease (IBD) management. One of the initial key considerations was the effect of immunosuppression on COVID-19 incidence and...

thelancet.com

Seroprevalence surveys in sub-Saharan Africa: what do they tell us?

Source: The Lancet

Opinion piece Initial estimates of the potential effect of SARS-CoV-2 virus in sub-Saharan Africa were catastrophic: fortunately, these predictions have not been met in terms of number of cases, deaths,...

thelancet.com

Prevalence of SARS-CoV-2 in six districts in Zambia in July, 2020: a cross-sectional cluster sample survey

Source: The Lancet

Peer review article The number of SARS-CoV-2 infections is likely to be higher than the confirmed case counts because many infected people have mild or no symptoms, and limitations exist...

thelancet.com

Surveillance of SARS-CoV-2 in Zimbabwe shows dominance of variants of concern

Source: The Lancet

Opinion piece The recent, worldwide spread of variants of concern has highlighted the need for global vigilance. Prospective surveillance of SARS-CoV-2 by genome sequencing in Zimbabwe between December, 2020, and...

thelancet.com

Children and young people remain at low risk of COVID-19 mortality

Source: The Lancet

Report on peer reviewed article Evidence indicates that children continue to be mostly, but not completely, spared the worst outcome of the pandemic, particularly compared with older adults who have...

blogs.bmj.com

Children and the return to school: how much should we worry about COVID-19 and long covid?

Source: BMJ

Opinion piece The clinical presentation and immune profile in those children who are hospitalised seems similar to the disease in adults. An exception to this is the relatively small subset...

bmj.com

Risk of mortality in patients infected with SARS-CoV-2 variant of concern 202012/1: matched cohort study

Source: BMJ

Peer reviewed article The probability that the risk of mortality is increased by infection with VOC-202012/01 is high. If this finding is generalisable to other populations, infection with VOC-202012/1 has...

cdc.gov

How CDC is responding to SARS-CoV-2 variants globally

Source: US CDC

Latest updates on how the CDC is responding to SARS-CoV-2 variants globally.

cdc.gov

Body Mass Index and Risk for COVID-19–Related Hospitalization, Intensive Care Unit Admission, Invasive Mechanical Ventilation, and Death — United States, March–December 2020

Source: US CDC

Research Study A clinical study finds that overweight and obesity were risk factors for invasive mechanical ventilation. Obesity was a risk factor for hospitalization and death, particularly among adults aged

jwatch.org

SARS-CoV-2 Reinfection Uncommon, but Older Adults Seem at Higher Risk

Source: NEJM

Report on peer reviewed article Research finds that SARS-CoV-2 reinfection is uncommon, but older adults seem at higher risk. The reinfection rate was 8 per 100,000 person among people aged...

thelancet.com

Assessment of protection against reinfection with SARS-CoV-2 among 4 million PCR-tested individuals in Denmark in 2020: a population-level observational study

Source: Lancet

Peer review article Using Danish national PCR-test data from 2020, the study estimates protection towards repeat infection with SARS-CoV-2. It found protection against repeat infection was circa 80%, falling to...

thelancet.com

Seroprevalence and humoral immune durability of anti-SARS-CoV-2 antibodies in Wuhan, China: a longitudinal, population-level, cross-sectional study

Source: Lancet

Peer review article 6.92% of a cross-sectional sample of the population of Wuhan developed antibodies against SARS-CoV-2, with 39.8% of this population seroconverting to have neutralising antibodies. The data on...

thelancet.com

Sustained neutralising antibodies in the Wuhan population suggest durable protection against SARS-CoV-2

Source: Lancet

Report on peer reviewed article This study is an important milestone in the description of SARS-CoV-2 infection and our understanding of immunity in the pandemic.  The study detected neutralising antibodies...

thelancet.com

Long COVID: understanding the neurological effects

Source: Lancet

The concept of so-called long COVID has gained prominence in recent months, with some patients reporting persistent neurological manifestations, from milder symptoms such as headaches, hyposmia, hypogeusia, and fatigue to...

bmj.com

Covid-19: Eight in 10 Wuhan residents with antibodies had no symptoms, finds study

Source: BMJ

More than three quarters of Wuhan residents who tested positive for SARS-CoV-2 antibodies had experienced no COVID-19 symptoms and just under half developed long lasting neutralising antibodies, show results from...

jwatch.org

Mental Health Aftermath of COVID-19: Long-Hauler Depression?

Source: NEJM

Report of peer reviewed article Recent surveys during the COVID-19 pandemic have documented substantial rates of depression, anxiety, and overall distress in as many as one third of healthcare workers,...

jwatch.org

Predictors of “Long COVID-19”

Source: NEJM

Report on peer reviewed article This study suggests a relatively small fraction of symptomatic people with PCR-positive COVID-19 go on to develop chronic, debilitating symptoms. The people who were oldest,...

jwatch.org

Just How Much Protection Against SARS-CoV-2 Reinfection Does Prior Infection Provide?

Source: NEJM

Report on peer reviewed article Factors expected to influence reinfection rates in patients with previous SARS-CoV-2 infection include general immune status, time from initial infection, prevalence of viral variants, and...

thelancet.com

Dynamics of SARS-CoV-2 neutralising antibody responses and duration of immunity: a longitudinal study

Source: The Lancet

Pre-release of peer review article Neutralising antibody response dynamics in patients who have recovered from COVID-19 vary greatly, and prediction of immune longevity can only be accurately determined at the...

thelancet.com

Prevalence of RT-qPCR-detected SARS-CoV-2 infection at schools: First results from the Austrian School-SARS-CoV-2 prospective cohort study

Source: The Lancet

Peer review article This monitoring study in Austrian schools revealed SARS-CoV-2 infection in 0·39%-1·39% of participants and identified associations of regional community incidence and social deprivation with higher prevalence.

thelancet.com

Africa needs local solutions to face the COVID-19 pandemic

Source: The Lancet

Opinion piece In The Lancet, Stephanie Salyer and colleagues' comprehensive and elegant cross-sectional analysis of COVID-19 case counts, response measures, and mortality rates highlights the diversity of the COVID-19 burden...

thelancet.com

Pre-existing conditions are associated with COVID-19 patients’ hospitalization, despite confirmed clearance of SARS-CoV-2 virus

Source: The Lancet

Peer review article Overall, this retrospective study highlights specific pre-existing conditions that are associated with higher hospitalization rates in COVID-19 patients despite viral clearance and motivates follow-up prospective research into...

thelancet.com

The first and second waves of the COVID-19 pandemic in Africa: a cross-sectional study

Source: The Lancet

Peer review article Analysis showed that the African continent had a more severe second wave of the COVID-19 pandemic than the first, and highlights the importance of examining multiple epidemiological...

thelancet.com

First manifestation of adult-onset Still’s disease after COVID-19

Source: The Lancet

Opinion piece Adult-onset Still's disease (AOSD) is a rare inflammatory disorder that usually affects young adults, with a bimodal peak at ages 15–25 years and 36–46 years. Here, we report...

thelancet.com

Microvascular disease in diabetes and severe COVID-19 outcomes

Source: The Lancet

Opinion piece Microvascular disease has been associated with worse outcomes in people with diabetes admitted to hospital for COVID-19. Pre-existing endothelial dysfunction and diffuse microangiopathy, particularly in the pulmonary microcirculation,...

thelancet.com

Long COVID: understanding the neurological effects

Source: The Lancet

Opinion piece The concept of so-called long COVID has gained prominence in recent months, with some patients reporting persistent neurological manifestations, from milder symptoms such as headaches, hyposmia, hypogeusia, and...

bmj.com

Covid-19: Middle aged women face greater risk of debilitating long term symptoms

Source: BMJ

Middle aged women have a higher risk of experiencing a range of debilitating ongoing symptoms, such as fatigue, breathlessness, muscle pain, anxiety, depression, and “brain fog” after hospital treatment for...

jwatch.org

How Does Living with Children Affect Adults’ Risk for COVID-19 and Its Outcomes?

Source: NEJM

Report on peer reviewed article These data indicate that during the second wave of the pandemic in England, children appeared to have a role in the transmission of SARS-CoV-2. However,...

jwatch.org

Neurologic Involvement in Children Hospitalized with SARS-CoV-2 Infection

Source: NEJM

Report on peer reviewed article This snapshot of paediatric patients hospitalised with acute or postinfectious COVID-19 or MIS-C describes the commonly occurring neurologic symptoms and highlights that in rare cases...

jwatch.org

who-china-study-sars-cov-2-likely-came-intermediary-host

Source: NEJM

Report on peer reviewed article The most probable origin of the SARS-CoV-2 virus was an intermediary animal host, states a joint report from the World Health Organization and experts from...

jwatch.org

Return to Activity After COVID-19: Lessons from Professional Sports

Source: NEJM

Report on peer reviewed article These findings from a large and well-performed study demonstrate that cardiac involvement is rare after mild or asymptomatic COVID-19 (

jwatch.org

COVID-19: Post-Discharge Organ Damage, Death / B.1.1.7 Rising in U.S. / Mortality in 2020 / WHO on Ivermectin

Source: NEJM

Report on peer reviewed article Patients discharged following a hospital stay for COVID-19 are at increased risk for mortality, readmission, and organ dysfunction, finds a study in the BMJ. The...

ecdc.europa.eu

ECDC report examines SARS-CoV-2 transmission risk from vaccinated/previously infected individuals

Source: EU CDC

In the Technical Report 'Risk for SARS-CoV-2 transmission from newly infected individuals with documented previous infection or vaccination', published today, ECDC examines the evidence on the extent previous SARS-CoV-2 infection...

thelancet.com

Association between pre-existing respiratory disease and its treatment, and severe COVID-19: a population cohort study

Source: The Lancet

Peer review article The risk of severe COVID-19 in people with asthma is relatively small. People with COPD and interstitial lung disease appear to have a modestly increased risk of...

thelancet.com

Short-term safety of the BNT162b2 mRNA COVID-19 vaccine in patients with cancer treated with immune checkpoint inhibitors

Source: The Lancet

Experts at the Israeli National Council for Prevention Diagnosis and Treatment of Malignant Disease raised concerns regarding the ability of the vaccine to provoke or enhance immune-related side-effects in patients...

thelancet.com

Anterior uveitis in paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2

Source: The Lancet

Opinion piece COVID-19 in children and adolescents generally only causes mild symptoms. However, an immune response with persistent fever, inflammation, and single or multiorgan dysfunction, without any microbial cause, but...

bmj.com

Post-covid syndrome in individuals admitted to hospital with covid-19: retrospective cohort study

Source: BMJ

Individuals discharged from hospital after Covid-19 had increased rates of multiorgan dysfunction compared with the expected risk in the general population. The increase in risk was not confined to the...

who.int

WHO calls for further studies, data on origin of SARS-CoV-2 virus, reiterates that all hypotheses remain open

Source: WHO

The report of the WHO international team on their Wuhan field visit, from 14 January -10 February 2021, was published today. The WHO’s Director General noted that while the reports...

jwatch.org

Does Blood Group Type A Confer Excess Risk for SARS-CoV-2 Infection?

Source: NEJM

Report on peer review article The positive findings in this study for risk associated with age and sex strengthen the validity of the negative findings for blood group type. If...

jwatch.org

COVID-19: Neurologic & Psychiatric Sequelae / MIS-C Update

Source: NEJM

According to a retrospective study in The Lancet Psychiatry, risks for neurologic and psychiatric morbidity are significantly increased in the months after COVID-19 diagnosis.

In an update on Multisystem Inflammatory Syndrome...

jwatch.org

1 in 7 Report Persistent Symptoms After Mild COVID-19

Source: NEJM

Roughly 15% of patients who had mild COVID-19 symptoms still had symptoms 8 months later, according to a JAMA research letter. The most common prolonged symptoms were anosmia, fatigue, ageusia,...

nejm.org

Susceptibility of Circulating SARS-CoV-2 Variants to Neutralization

Source: NEJM

Findings suggest that B.1.1.7 showed little resistance to the neutralizing activity of convalescent or vaccine serum, whereas B.1.351 showed more resistance to the neutralization of both convalescent serum (by a...

thelancet.com

Incident systemic rheumatic disease following COVID-19

Source: The Lancet

Although viruses can induce rheumatic diseases, the impact of SARS-CoV-2, the virus behind COVID-19, on the development of systemic rheumatic disease is unclear. COVID-19 can cause a hyperinflammatory state, and...

thelancet.com

A longer look at COVID-19 and neuropsychiatric outcomes

Source: The Lancet

Report on peer review article In the 6 months after SARS-CoV-2 infection, about a third of individuals had a neurological or psychiatric disorder, substantially more than comparative figures for influenza....

thelancet.com

6-month neurological and psychiatric outcomes in 236 379 survivors of COVID-19: a retrospective cohort study using electronic health records

Source: The Lancet

Pre-release peer review article The study provides evidence for substantial neurological and psychiatric morbidity in the 6 months after COVID-19 infection. Risks were greatest in, but not limited to, patients...

thelancet.com

Recorded but not revealed: exploring the relationship between sex and gender, country income level, and COVID-19

Source: The Lancet

Identifying the contribution of sex and gender to SARS-CoV-2 infection yields important evidence on both biological mechanisms that underlie differences in illness outcomes, and social and structural dynamics that influence...

thelancet.com

Distinguishing the real from the hyperglycaemia: does COVID-19 induce diabetes?

Source: The Lancet

Report on peer review article The potential role of SARS-CoV-2 in inducing diabetes is likely to be more complex than the mere notion of pancreatic ACE2 expression and β-cell destruction....

thelancet.com

Calls for transparency after SARS-CoV-2 origins report

Source: The Lancet

Opinion piece As focus shifts to the next phase of research on the origins of SARS-CoV-2, calls for data sharing and more rigorous studies intensify. The publication on March 30,...

thelancet.com

COVID-19 severity and obesity: are MAIT cells a factor?

Source: The Lancet

Report on peer review article People with obesity have an increased risk of severe COVID-19. A meta-analysis by Popkin and colleagues found that the odds ratio of people with obesity...

thelancet.com

Pandemic fans the flames of smoking and health inequity

Source: The Lancet

Opinion piece During the COVID-19 pandemic, evidence suggests that fewer people are stopping smoking and more ex-smokers are relapsing. This finding is especially concerning because smokers are at a higher...

thelancet.com

“In an ocean of ashes, islands of order”: WHO’s SARS-CoV-2 origin report

Source: The Lancet

Opinion piece The WHO’s report on the origin of SARS-CoV-2 was released on March 30. 34 international and Chinese multidisciplinary experts reviewed hundreds of thousands of epidemiological, clinical, and genomic...

bmj.com

Covid-19: One in three has neurological or psychiatric condition diagnosed after covid infection, study finds

Source: BMJ

Report on peer review article When compared with people who had flu or other respiratory tract infections over the same period, COVID-19 survivors were more likely to have conditions such...

cdc.gov

Post-COVID Conditions

Source: US CDC

Although most people with COVID-19 get better within weeks to months of illness, some do not. CDC and experts around the world are working to learn more about short- and...

cks.nice.org.uk

When should I suspect coronavirus infection?

Source: National Institute for Health and Care Excellence (NICE)

COVID-19 is spread by droplets from sneezing and coughing. Common symptoms are: fever, new and continuous cough, shortness of breath, loss of appetite, loss of smell, and loss of taste....

cks.nice.org.uk

Coronavirus – COVID 19

Source: National Institute for Health and Care Excellence (NICE)

COVID-19 is a novel coronavirus, thought to originally be hosted in bats, which emerged in China in 2019. This is mainly a respiratory illness. The most common symptoms are fever,...

thelancet.com

COVID-19 in Africa: half a year later

Source: The Lancet

This article provides a retrospective on the first months of COVID-19 in Africa. Across Africa, readiness in surveillance, laboratory capacity, case management, and infection prevention has increased (as scored by...

africacdc.org

US$100 million Africa Pathogen Genomics Initiative to boost disease surveillance and emergency response capacity in Africa

Source: Africa CDC

On the 12th of October, the Africa Pathogen Genomics Initiative (Africa PGI) was launched to expand access to next-generation sequencing (NGS) tools and expertise across Africa. Next-generation sequencing allows researchers...

africacdc.org

Statement on new SARS-CoV-2 variant with multiple spike protein mutations

Source: Africa CDC

The Africa CDC is raising awareness of the new variant of SARS-CoV-2 reported in South Africa and the United Kingdom (UK). SARS-CoV-2 is the virus which causes COVID-19. This new...

afro.who.int

WHO urges greater surveillance as new COVID-19 variants emerge

Source: WHO African Region

New variants of SARS-CoV-2, the virus which causes COVID-19, are being detected in the African region. These variants appear to transmit more easily, and the new variant recently detected in...

who.int

Coronavirus Update 42: What we know about COVID-19 and mink

Source: WHO

While SARS-CoV-2 spreads mainly through and between humans, transmission has been observed between infected humans and mink, dogs, domestic cats, lions, tigers and raccoon dogs. SARS-CoV-2 has been reported in...

africacdc.org

COVID-19 Scientific and Public Health Policy Update – (17 November 2020)

Source: Africa CDC

This update provides a summary of the latest developments in scientific knowledge and public health policy from around the world. Highlights on epidemiology are summarised below: - An analysis of...

thelancet.com

Quantitative assessment of olfactory dysfunction accurately detects asymptomatic COVID-19 carriers

Source: The Lancet

Detecting and isolating asymptomatic COVID-19 cases is key in limiting the spread of the disease, as asymptomatic people can still transmit SARS-CoV-2. There have been reports from COVID-19 patients of...

gh.bmj.com

Predicted COVID-19 fatality rates based on age, sex, comorbidities and health system capacity

Source: BMJ

The Infection Fatality Rate (IFR) is the proportion of people infected with the virus who will die as a result - this captures asymptomatic and undiagnosed cases through statistical modelling....

whotogo-whoafroccmaster.newsweaver.com

Noncommunicable diseases increase risk of dying from COVID-19 in Africa

Source: WHO African Region

Evidence is showing that Africans with non-communicable diseases (NCDs) such as hypertension, diabetes, cardiovascular disease, and asthma are more at risk of suffering severe complications or death from COVID-19 infection....

whotogo-whoafroccmaster.newsweaver.com

Nearly 1 in 5 COVID-19 deaths in the African region linked to diabetes

Source: WHO African Region

The WHO has analysed data on COVID-19 and comorbidities from 14 African countries and has found that 18.3% of COVID-19 deaths in the African region are among people with diabetes,...

africacdc.org

COVID-19 Scientific and Public Health Policy Update – (01 December 2020)

Source: Africa CDC

This update provides a summary of the latest developments in scientific knowledge and public health policy from around the world. Highlights on epidemiology are summarised below: - In a large,...

thelancet.com

HIV infection and COVID-19 death: a population-based cohort analysis of UK primary care data and linked national death registrations within the OpenSAFELY platform

Source: The Lancet

People with HIV in the UK seem to be at increased risk of COVID-19 mortality: A study on COVID-19 patients living with HIV in England found that people living with...

who.int

Coronavirus Update 36: What we know about long-term effects of COVID-19

Source: WHO

Most people with COVID-19 experience mild or moderate symptoms, however around 10-15% of cases progress to severe disease and around 5% become critically ill. People typically recover from COVID-19 2-6...

africacdc.org

COVID-19 Scientific and Public Health Policy Update – (15 December 2020)

Source: Africa CDC

This update provides a summary of the latest developments in scientific knowledge and public health policy from around the world. Highlights on epidemiology are summarised below: - Adults over 60...

who.int

Mask use in the context of COVID-19

Source: WHO

The WHO advises that masks should be used along with other control measures to help prevent and control the spread of COVID-19. Guidance is provided on the types of masks...

who.int

Coronavirus Update 40: Overview of the COVID-19 pandemic

Source: WHO

The website: https://covid19.who.int/table provides updates on case numbers and fatalities. Coronaviruses are a large family of viruses which are known to circulate in animals and humans, some of which can...

who.int

Coronavirus disease (COVID-19) advice for the public

Source: WHO

The most common symptoms of COVID-19 are fever, dry cough, and tiredness. Less common symptoms include loss of taste or smell, aches and pains, headache, sore throat, nasal congestion, red...

jwatch.org

COVID-19: Persistent Symptoms After Mild Illness / When to Test Student Contacts? / Pulse Oximetry Limitations

Source: NEJM

Review on research article Persistent symptoms after mild illness: One third of patients with mild COVID-19 may report ongoing symptoms 6 months later, according to a small study

jwatch.org

Patients with COVID-19 Are Unlikely to Survive In-Hospital Cardiac Arrest

Source: NEJM

Report on research article Most critically ill patients with COVID-19 have moderate-to-severe hypoxemia, and outcomes for patients with in-hospital arrest in the setting of hypoxemic respiratory failure generally are poor.

jwatch.org

COVID-19: Reinfections / New Name for “Long COVID” / IL-6 Inhibitor / NYC & Calif. Variants

Source: NEJM

Report on research articles COVID-19 reinfections confirmed in US; Interleukin-6 (a protein linked to inflammation) inhibitors as a promising therapy for COVID-19 and; further information on the spread of variants.

jwatch.org

Does Neonatal Protection Against COVID-19 Begin with Prenatal Maternal Antibodies

Source: NEJM

Report on research article These findings are reassuring in showing that pregnant women infected with SARS-CoV-2 can efficiently transfer anti–spike protein IgG antibodies to their foetuses, thereby helping to protect...

jwatch.org

SARS-CoV-2 Reinfection with a Mutant Viral Variant: A Case Study

Source: NEJM

Opinion piece Official report on case of infection and reinfection by two different SARS-CoV-2 strains.

thelancet.com

Anticipating outcomes for patients with COVID-19 and identifying prognosis patterns

Source: The Lancet

Opinion piece Older age, male sex and increased body-mass index are all linked again to increased chances of severe COVID-19 infections.

thelancet.com

Tuberculosis preventive therapy for children and adolescents: an emergency response to the COVID-19 pandemic

Source: The Lancet

Opinion piece The provision of tuberculosis preventive therapy for all forms of tuberculosis should be seen as an emergency measure to combat the devastating effect of COVID-19 on tuberculosis,

thelancet.com

Pre-pandemic mental illness and risk of death from COVID-19

Source: The Lancet

Opinion piece It has been found that a diagnosis of poor mental health was associated with an increased risk of COVID-19.

thelancet.com

COVID-19 hindering progress against female genital mutilation

Source: The Lancet

Opinion piece The alarming signals of rising FGM cases are part of a broader context in which the COVID-19 pandemic has disproportionately impacted women's wellbeing—from increases in domestic violence, to...

cdc.gov

For Parents: Multisystem Inflammatory Syndrome in Children (MIS-C) associated with COVID-19

Source: US CDC

Multisystem inflammatory syndrome in children (MIS-C) is a condition where different body parts can become inflamed, including the heart, lungs, kidneys, brain, skin, eyes, or gastrointestinal organs. Many children with...

cdc.gov

COVID-19 Science Update released: February 26, 2021 Edition 78

Source: US CDC

A round up of recent scientific research and factual reports.

nejm.org

Duration of Culturable SARS-CoV-2 in Hospitalized Patients with Covid-19

Source: New England Journal of Medicine

A letter by Min-Chul Kim, M.D., Ph.D. Chung-Ang University Hospital, Seoul, South Korea, Chunguang Cui, M.Sc. Kyeong-Ryeol Shin, M.Sc. Joon-Yong Bae, Ph.D. Korea University College of Medicine, Seoul, South Korea...

nejm.org

Shedding of Viable SARS-CoV-2 after Immunosuppressive Therapy for Cancer

Source: New England Journal of Medicine

A letter by Teresa Aydillo, Ph.D. Ana S. Gonzalez-Reiche, Ph.D. Sadaf Aslam, B.A. Adriana van de Guchte, M.S. Zenab Khan, B.S. Ajay Obla, Ph.D. Jayeeta Dutta, M.B.A. Harm van Bakel,...

ecdc.europa.eu

Infographic: Mutation of SARS-CoV2 – current variants of concern

Source: ECDC

A new infographic from the ECDC showing facts and figures about the three leading variants of the SARS CoV-2 virus.

bmj.com

Covid-19: New UK variant may be linked to increased death rate, early data indicate

Source: BMJ

A briefing paper published on 22 January by the UK Government’s New and Emerging Respiratory Virus Threats Advisory Group (NERVTAG) highlighted several preliminary analyses showing a possible increase in the...

cdc.gov

US COVID-19 Cases Caused by Variants

Source: US CDC

This update from the CDC shows the numbers of US COVID-19 cases caused by new variants of the virus. New variants (also known as new strains) of the virus randomly...

snopes.com

How To Interpret That ‘1 in 8 Recovered COVID Patients Die’ Study

Source: Snopes

This statistic is based on a preliminary draft of a large scale study investigating the long-term outcome of COVID-19 patients in the UK who were hospitalized, recovered and released. The...

nejm.org

Vaccinating Children against Covid-19 — The Lessons of Measles

Source: New England Journal of Medicine

This is an opinion piece by Perri Klass, M.D., and Adam J. Ratner, M.D., M.P.H from the Grossman School of Medicine, New York University, New York. They argue that vaccinating...

thelancet.com

Household transmission of SARS-CoV-2 and risk factors for susceptibility and infectivity in Wuhan: a retrospective observational study

Source: The Lancet

This study looked at households of all laboratory-confirmed or clinically confirmed COVID-19 cases and laboratory-confirmed asymptomatic SARS-CoV-2 infections identified by the Wuhan Center for Disease Control and Prevention between Dec...

afro.who.int

New COVID-19 variants fuelling Africa’s second wave

Source: WHO

A new COVID-19 variant, 501Y.V2, known as the South African variant, has been detected in many countries including Botswana, Ghana, Kenya, Comoros, Zambia and in 24 non-African nations. It is...

jwatch.org

People with HIV Have Poorer COVID-19 Outcomes

Source: NEJM

Review  Although HIV-seropositive people are not more likely to be diagnosed with COVID-19 than HIV-seronegative people, they have poorer clinical outcomes, according to a JAMA Network Open report. Researchers studied...

jwatch.org

How Long Does Immunity Last After Recovery from Mild COVID-19?

Source: NEJM

Gaebler at al. assessed humoral memory (the presence of viral fighting protein in the blood stream body fluids) and responses in 87 patients at both 40 days and 6 months...

thelancet.com

Evaluating the effects of cardiometabolic exposures on circulating proteins which may contribute to severe SARS-CoV-2

Source: The Lancet

Research paper  Looking at the way SARS-CoV-2 causes disease in people is important in being able to control and fight it. Scientists are looking at the proteins (biological building blocks)...

thelancet.com

Understanding variants of SARS-CoV-2

Source: The Lancet

Opinion piece All viruses mutate. But three variants of SARS-CoV-2 have raised particular concerns. On Jan 21, 2021, the UK New and Emerging Respiratory Virus Threats Advisory Group (NERVTAG) issued...

thelancet.com

Factors associated with the spatial heterogeneity of the first wave of COVID-19 in France: a nationwide geo-epidemiological study

Source: The Lancet

This ecological study highlights the impact of the epidemic spread, national lockdown, and reactive adaptation of intensive care capacities on the spatial distribution of COVID-19 morbidity and mortality. It provides...

bmj.com

Covid-19: The E484K mutation and the risks it poses

Source: BMJ

The mutation E484K, first identified in the South African SARS-CoV-2 variant, has now been identified in the UK fast-spreading variant, prompting fears the virus is evolving further and could become...

bmj.com

Covid-19: Four in 10 people with evidence of past infection had no classic symptoms, study finds

Source: BMJ

News article  Around one in four people who had evidence of past COVID-19 infection were completely asymptomatic, while 40% did not have one of the three classic symptoms—fever, persistent dry...

africacdc.org

New SARS-CoV-2 variants in Africa

Source: Africa CDC

Africa is currently experiencing an increase in the number of confirmed COVID-19 cases. As of 27 January 2021, at least 40 countries have experienced a second wave of the pandemic,...

bmj.com

Covid-19: Sore throat, fatigue, and myalgia are more common with new UK variant

Source: BMJ

People infected with the new variant of COVID-19 discovered in the England (known as B.1.1.7 or VUI 202012/01) are more likely to have a cough, sore throat, fatigue, or myalgia...

bmj.com

Covid-19: WHO warns against “vaccine nationalism” or face further virus mutations

Source: BMJ

WHO officials have voiced concerns at “vaccine nationalism” which could increase the risk of the coronavirus mutating further by restricting the ability to distribute vaccines globally. They also noted that...

cdc.gov

New Variants of the Virus that Causes COVID-19

Source: USCDC

Viruses constantly change through mutation, and new variants of a virus are expected to occur over time. Sometimes new variants emerge and disappear; sometimes they persist. Variants of the virus...